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KMID : 0385020020180030097
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Korean Journal of Laboratory Animal Science
2002 Volume.18 No. 3 p.97 ~ p.103
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Transgenic Mouse Model for Human Cancers by Conditional Inactivation of p53 and Rb
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Choi, Kyung-Chul
Nikitin, AlexanderY./Lee, Yong-Soon/Jeung, Eui-Bae
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Abstract
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Future progress in early diagnosis, treatment and prevention of human cancers greatly depends on availability of accurate animal models. Ideally, such models have well-defined molecular alteration and morphological features mimicking human diseases. In this reviews, we describe a new design for modeling human cancers in mice. Most important features of our modeling approach are 1) inactivation of tumor suppressors p53 and Rb known to contribute in the development of human cancers, and 2) precise controlling of this inactivation in time, space and cell lineage. Temporal and spatial regulation of gene inactivation using Cre-loxP system allows defining the sequential stages of carcinogenesis. Such access to the atypical cells allows for the rational design and testing of tumor cell targeting based on functional identification of molecular and cellular markers of carcinogenesis. It also lays a solid groundwork for the development of new diagnostic and prognostic criteria for early detection and treatment of human cancers. Taken together, our approach can overcome main disadvantages of currently available models for human cancers and provide a genetically defined testing system for preclinical experiments on the carcinogenesis associated with deficiency of p53 and Rb.
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KEYWORD
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